Journal of Pharmacology and Experimental Therapeutics

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  Año 2004, Vol. 311, Número 3

  • The Functional Role of Threonine-205 in the Mechanism-Based Inactivation of P450 2B1 by Two Ethynyl Substrates: The Importance of the F Helix in Catalysis

    H.-L. Lin, U. M. Kent

    págs. 855-863

    

  • Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activated Receptor-alpha Target Gene Activation

    T. C. McCarthy

    págs. 864-873

    

  • Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days

    Y. Masada, H. Sakai, H. Horinouchi

    págs. 874-884

    

  • Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin beta-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells

    S. M. Moore, A. K. Jain, K. Yamaguchi

    págs. 885-891

    

  • Protein Kinase C Mediates Cisplatin-Induced Loss of Adherens Junctions Followed by Apoptosis of Renal Proximal Tubular Epithelial Cells

    B. van de Water, R. Imamdi, M. de Graauw

    págs. 892-903

    

  • ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxygenase-2 Inhibitor

    R. R. Harris

    págs. 904-912

    

  • Transfection and Functional Expression of CYP4A1 and CYP4A2 Using Bicistronic Vectors in Vascular Cells and Tissues

    J.-S. Wang

    págs. 913-920

    

  • Contribution of Angiotensin II to Alcohol-Induced Pancreatic Fibrosis in Rats

    T. Uesugi

    págs. 921-928

    

  • Evaluation of Second Generation Amiloride Analogs as Therapy for Cystic Fibrosis Lung Disease

    A. J. Hirsh, J. R. Sabater

    págs. 929-938

    

  • Differential Sensitivity of N- and P/Q-Type Ca^2^+ Channel Currents to a mu Opioid in Isolectin B~4-Positive and -Negative Dorsal Root Ganglion Neurons

    Z.-Z. Wu, S.-R. Chen

    págs. 939-947

    

  • Rotenone Induces Apoptosis via Activation of Bad in Human Dopaminergic SH-SY5Y Cells

    M. Watabe, T. Nakaki

    págs. 948-953

    

  • Interaction between Dinucleotide and Nicotinic Receptors in Individual Cholinergic Terminals

    M. Diaz-Hernandez, J. Sanchez-Nogueiro

    págs. 954-967

    

  • Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays

    M. Nouzova, N. Holtan, M. M. Oshiro

    págs. 968-981

    

  • Gene Therapy with Adenoviral Plasmids or Naked DNA of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Accelerates Healing of Duodenal Ulcer in Rats

    X. Deng, M. R. Jadus, T. Khomenko, S. Szabo

    págs. 982-988

    

  • Anti-Inflammatory Effects of AT1 Receptor Blockade Provide End-Organ Protection in Stroke-Prone Rats Independently from Blood Pressure Fall

    U. Guerrini, L. Sironi, P. Gelosa

    págs. 989-995

    

  • Mechanism-Based Inactivation of Human Cytochrome P4502C8 by Drugs in Vitro

    T. M. Polasek, D. J. Elliot

    págs. 996-1007

    

  • Effects of Dopamine D~1 Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D~1/D~2 Interactions

    E. M. Jutkiewicz

    págs. 1008-1015

    

  • Volatile Anesthetics Inhibit Calcitonin Gene-Related Peptide Receptor-Mediated Responses in Pithed Rats and Human Neuroblastoma Cells

    K. Nishikawa, D. Yoshikawa, M. Kuroda

    págs. 1016-1022

    

  • Apolipoprotein A-I~M~i~l~a~n~o and 1-Palmitoyl-2-oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury

    M. Marchesi, E. A. Booth

    págs. 1023-1031

    

  • Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells

    T. Nozawa, K. Takahashi, M. Suzuki

    págs. 1032-1037

    

  • Induction of Novel Agonist Selectivity for the ADP-Activated P2Y~1 Receptor Versus the ADP-Activated P2Y~1~2 and P2Y~1~3 Receptors by Conformational Constraint of an ADP Analog

    M. Chhatriwala

    págs. 1038-1043

    

  • Repeated Amphetamine Couples Norepinephrine Transporter and Calcium Channel Activities in PC12 Cells

    B. Guptaroy, M. Zhang, L. Kantor

    págs. 1044-1051

    

  • Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats

    S. P. Tofovic, P. A. Sonalker, E. K. Jackson

    págs. 1052-1061

    

  • Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

    J. K. Kwon, C.-D. Kang, J. H. Um

    págs. 1062-1070

    

  • Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABA~A Receptors in Basolateral Amygdala

    D. W. Floyd, D. P. Friedman

    págs. 1071-1079

    

  • Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2'-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model

    C. Demougeot, M. Van Hoecke

    págs. 1080-1087

    

  • Genetic Variants of the Human H^+/Dipeptide Transporter PEPT2: Analysis of Haplotype Functions

    J. Pinsonneault

    págs. 1088-1096

    

  • Potentiation of the Osmosensitive Release of Taurine and D-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M~3 Muscarinic Cholinergic Receptors

    A. T. VanTroostenberghe, A. M. Heacock

    págs. 1097-1104

    

  • Inhibition of Tumor Cell Proliferation by sigma Ligands Is Associated with K^+ Channel Inhibition and p27^k^i^p^1 Accumulation

    A. Renaudo

    págs. 1105-1114

    

  • Effects of gamma- and Hydroxypropyl-gamma-cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier

    V. Monnaert, D. Betbeder

    págs. 1115-1120