Journal of Pharmacology and Experimental Therapeutics

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  Año 2005, Vol. 312, Número 3

  • Cannabinoid CB~1 Receptor Antagonists as Promising New Medications for Drug Dependence

    B. Le Foll, S. R. Goldberg

    págs. 875-883

    

  • Green Tea Polyphenol-Induced Epidermal Keratinocyte Differentiation Is Associated with Coordinated Expression of p57/KIP2 and Caspase 14

    S. Hsu, T. Yamamoto

    págs. 884-890

    

  • Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure

    C.-Y. Xiao

    págs. 891-898

    

  • Differential Effects on Current Kinetics by Point Mutations in the lurcher Motif of NR1/NR2A Receptors

    F. Zheng, B. Hu

    págs. 899-904

    

  • Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear

    O. Stiedl, M. Meyer

    págs. 905-916

    

  • YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G~0-G~1 in Human Hepatocellular Carcinoma Cells

    S.-W. Wang, S.-L. Pan, D.-M. Huang, H.-L. Chen, J.-H. Guh, Y.-L. Chang

    págs. 917-925

    

  • Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling

    J. B. Houston, A.-C. Egnell

    págs. 926-937

    

  • Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice

    A. Ishibashi, T. Yamauchi

    págs. 938-944

    

  • Cyclooxygenase-2 Inhibition Improves Vascular Endothelial Dysfunction in a Rat Model of Endotoxic Shock: Role of Inducible Nitric-Oxide Synthase and Oxidative Stress

    A. Virdis, R. Colucci

    págs. 945-953

    

  • Prostaglandin D~2-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

    Y. Shiraishi

    págs. 954-960

    

  • Amiloride Peptide Conjugates: Prodrugs for Sodium-Proton Exchange Inhibition

    H. Palandoken

    págs. 961-967

    

  • Induction of Nitric Oxide Production by the Cytostatic Macrolide Apicularen A [2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 Dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and Possible Role of Nitric Oxide in Apicularen A-Induced Apoptosis in RAW 264.7 Cells

    J. Hong, A. Yokomakura

    págs. 968-977

    

  • Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

    K. Kashfi, S. Borgo, J. L. Williams

    págs. 978-988

    

  • In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism

    K. Kashfi, Jianjun Gao

    págs. 989-997

    

  • Protein Kinase C Signaling as a Survival Pathway against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells

    J. M. Jimenez-Lopez

    págs. 998-1006

    

  • Mixed-Lineage Kinase Inhibitors Require the Activation of Trk Receptors to Maintain Long-Term Neuronal Trophism and Survival

    E. M. Johnson, A. J. Paden, L. H. Wang

    págs. 1007-1019

    

  • Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

    T. O. Harasym, S. C. Semple

    págs. 1020-1026

    

  • Ciglitazone-Induced Lenticular Opacities in Rats: In Vivo and Whole Lens Explant Culture Evaluation

    K. A. Navetta, C. M. Doshna, M. D. Aleo

    págs. 1027-1033

    

  • Dual, Hyperalgesic, and Analgesic Effects of the High-Efficacy 5-Hydroxytryptamine 1A (5-HT~1~A) Agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, Fumaric Acid Salt]: Relationship with 5-HT~1~A Receptor Occupancy and Kinetic Parameters

    M.-B. Assie, I. Royer-Urios, M. Pelissou, A. Newman-Tancredi, L. Bardin

    págs. 1034-1042

    

  • Angiotensin II-Induced Akt Activation through the Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells Is Mediated by Phospholipid Metabolites Derived by Activation of Phospholipase D

    Fang Li, K. U. Malik

    págs. 1043-1054

    

  • Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats

    E. L. Eberle, C. K. Jones

    págs. 1055-1063

    

  • Evidence for Pleiotropic Signaling at the Mouse beta~3-Adrenoceptor Revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol Oxalate]

    D. S. Hutchinson

    págs. 1064-1074

    

  • A Tyr-W-MIF-1 Analog Containing D-Pro^2 Acts as a Selective mu~2-Opioid Receptor Antagonist in the Mouse

    D. Nakayama, H. Watanabe

    págs. 1075-1081

    

  • Differential GABA~B Receptor Modulation of Ethanol Effects on GABA~A Synaptic Activity in Hippocampal CA1 Neurons

    W. R. Proctor, P. H. Wu, W. Poelchen

    págs. 1082-1089

    

  • Renal D-Amino Acid Oxidase Mediates Chiral Inversion of N^G-Nitro-D-arginine

    Y.-F. Xin, X.-J. Zhou

    págs. 1090-1096

    

  • Ethyl Pyruvate Inhibits Nuclear Factor-kappaB-Dependent Signaling by Directly Targeting p65

    J. A. Englert, Y. Han

    págs. 1097-1105

    

  • Blood Clearance and Activity of Erythrocyte-Coupled Fibrinolytics

    K. Ganguly, S. Medinilla, T. Krasik

    págs. 1106-1113

    

  • [(pF)Phe^4,Arg^1^4,Lys^1^5]N/OFQ-NH~2 (UFP-102), a Highly Potent and Selective Agonist of the Nociceptin/Orphanin FQ Receptor

    A. Rizzi, R. Guerrini, G. Carra, T. A. Barnes

    págs. 1114-1123

    

  • Dopamine Uptake Inhibitor-Induced Rotation in 6-Hydroxydopamine-Lesioned Rats Involves Both D~1 and D~2 Receptors but Is Modulated through 5-Hydroxytryptamine and Noradrenaline Receptors

    S. Cheetham, E. L. Lane

    págs. 1124-1131

    

  • Quantitative and Fiber-Selective Evaluation of Dose-Dependent Nerve Blockade by Intrathecal Lidocaine in Rats

    M. Oda, N. Kitagawa

    págs. 1132-1137