Journal of Pharmacology and Experimental Therapeutics

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  Año 2005, Vol. 313, Número 1

  • Ligand Discovery Using Small Molecule Microarrays

    X. G. He, G. Gerona-Navarro

    págs. 1-7

    

  • Therapeutic Dosing with Anti-Interleukin-13 Monoclonal Antibody Inhibits Asthma Progression in Mice

    G. Yang

    págs. 8-15

    

  • Heterodimerization with beta~2-Adrenergic Receptors Promotes Surface Expression and Functional Activity of alpha~1~D-Adrenergic Receptors

    M. A. Uberti

    págs. 16-23

    

  • High-Affinity Epibatidine Binding of Functional, Human alpha7-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed de Novo in Human SH-EP1 Cells

    J. D. Fryer, R. S. Hurst, J.-H. Peng, K. M. Schroeder

    págs. 24-35

    

  • Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and an Angiotensin II Receptor Blocker Synergistically Suppresses Chronic Pancreatitis in Rats

    T. Yamada

    págs. 36-45

    

  • Protein Kinase Cdelta Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells

    C. Latchoumycandane

    págs. 46-55

    

  • A Novel Benzodiazepine Selectively Inhibits Keratinocyte Proliferation and Reduces Retinoid-Induced Epidermal Hyperplasia in Organ-Cultured Human Skin

    N. Bhagavathula, J. Varani

    págs. 56-63

    

  • Effects of Prostaglandin D~2, 15-Deoxy-Delta^1^2^,^1^4-prostaglandin J~2, and Selective DP~1 and DP~2 Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats

    W. Almishri, C. Cossette

    págs. 64-69

    

  • Vascular Dysfunction of Venous Bypass Conduits Is Mediated by Reactive Oxygen Species in Diabetes: Role of Endothelin-1

    A. Ergul, J. S. Johansen

    págs. 70-77

    

  • A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein alpha Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity

    E. Kostenis, L. Martini

    págs. 78-87

    

  • Involvement of Protein Kinase A in Cannabinoid Receptor-Mediated Protection from Oxidative Neuronal Injury

    X. O. Mao, S. H. Kim, S. J. Won

    págs. 88-94

    

  • 1,1-Dichloroethylene-Induced Mitochondrial Damage Precedes Apoptotic Cell Death of Bronchiolar Epithelial Cells in Murine Lung

    E. J. Martin, P.-G. Forkert

    págs. 95-103

    

  • Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes

    O. Sergent, M. Pereira, M. Chevanne, C. Belhomme

    págs. 104-111

    

  • Trimers of N-Alkylglycines Are Potent Modulators of the Multidrug Resistance Phenotype

    M. J. Abad-Merin

    págs. 112-120

    

  • Bradykinin Down-Regulates, Whereas Arginine Analogs Up-Regulate, Endothelial Nitric-Oxide Synthase Expression in Coronary Endothelial Cells

    N. D. Vaziri

    págs. 121-126

    

  • Mechanisms of Interleukin-4 Effects on Calcium Signaling in Airway Smooth Muscle Cells

    E. Cappelluti, J. M. Madison, M. F. Ethier

    págs. 127-133

    

  • Intracranial Self-Administration of Cocaine within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons

    R. L. Bell, Z. A. Rodd

    págs. 134-145

    

  • Electrophysiological Effects of Prucalopride, a Novel Enterokinetic Agent, on Isolated Atrial Myocytes from Patients Treated with beta-Adrenoceptor Antagonists

    D. Pau, A. J. Workman

    págs. 146-153

    

  • The Grapefruit Juice Effect Is Not Limited to Cytochrome P450 (P450) 3A4: Evidence for Bergamottin-Dependent Inactivation, Heme Destruction, and Covalent Binding to Protein in P450s 2B6 and 3A5

    P. F. Hollenberg, H.-l. Lin, U. M. Kent

    págs. 154-164

    

  • Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and Selective Histamine H~3 Receptor Antagonist with Drug-Like Properties

    T. A. Esbenshade

    págs. 165-175

    

  • Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and Schizophrenia of a Potent and Selective Histamine H~3 Receptor Antagonist

    G. B. Fox, T. A. Esbenshade

    págs. 176-190

    

  • Suramin Disrupts Receptor-G Protein Coupling by Blocking Association of G Protein alpha and betagamma Subunits

    J. C. Kermode, W.-C. Chung

    págs. 191-198

    

  • A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

    J. A. O Brien, G. G. Kinney

    págs. 199-206

    

  • Modulation of Sarcoplasmic Reticulum Function by Na^+/K^+ Pump Inhibitors with Different Toxicity: Digoxin and PST2744 [(E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride]

    M. Rocchetti

    págs. 207-215

    

  • Antagonist Efficacy in MORS196L Mutant Is Affected by the Interaction between Transmembrane Domains of the Opioid Receptor

    P. A. Claude-Geppert, L. J. Erickson-Herbrandson

    págs. 216-226

    

  • Free Exchange across Cells, and Echistatin-Sensitive Membrane Target for the Metastasis Inhibitor NAMI-A (Imidazolium trans-Imidazole Dimethyl Sulfoxide Tetrachlororuthenate) on KB Tumor Cells

    V. Scarcia, M. Cocchietto, F. Frausin

    págs. 227-233

    

  • Proximal Tubular Toxicity of Ochratoxin A Is Amplified by Simultaneous Inhibition of the Extracellular Signal-Regulated Kinases 1/2

    H. Holzinger, C. Sauvant

    págs. 234-241

    

  • Somatostatin-Induced Activation and Up-Regulation of N-Methyl-D-aspartate Receptor Function: Mediation through Calmodulin-Dependent Protein Kinase II, Phospholipase C, Protein Kinase C, and Tyrosine Kinase in Hippocampal Noradrenergic Nerve Endings

    M. Feligioni, A. Pittaluga

    págs. 242-249

    

  • BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties

    S. Tertyshnikova

    págs. 250-259

    

  • Does Cyclic AMP Mediate Rat Urinary Bladder Relaxation by Isoproterenol?

    E. P. Frazier

    págs. 260-267