Journal of Pharmacology and Experimental Therapeutics

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  Año 2005, Vol. 313, Número 2

  • Altered Neurotrophism in Diabetic Neuropathy: Spelunking the Caves of Peripheral Nerve

    R. T. Dobrowsky

    págs. 485-517

    

  • AGIX-4207 [2-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic Acid], a Novel Antioxidant and Anti-Inflammatory Compound: Cellular and Biochemical Characterization of Antioxidant Activity and Inhibition of Redox-Sensitive Inflammatory Gene Expression

    C. Kunsch, J. Luchoomun

    págs. 492-528

    

  • Cilostazol Reduces Atherosclerosis by Inhibition of Superoxide and Tumor Necrosis Factor-alpha Formation in Low-Density Lipoprotein Receptor-Null Mice Fed High Cholesterol

    S. Y. Park, J. G. Park, G. T. Oh, J. H. Lee, J.-H. Choi

    págs. 502-538

    

  • Time-Dependent Changes in Receptor/G-Protein Coupling in Rat Brain following Chronic Monoamine Transporter Blockade

    H. M. L. Davies, K. A. O Connor, L. J. Porrino

    págs. 510-562

    

  • Selective Inhibition of Dog Hepatic CYP2B11 and CYP3A12

    S. B. Singh, P. Lu

    págs. 518-548

    

  • Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and the Development of Bleomycin-Induced Lung Injury

    T. Genovese

    págs. 529-577

    

  • Functional Interactions between 5-Hydroxytryptamine Receptors and the Serotonin Transporter in Pulmonary Arteries

    L. Loughlin, I. Morecroft

    págs. 539-556

    

  • Vectorial Transport of the Peptide CCK-8 by Double-Transfected MDCKII Cells Stably Expressing the Organic Anion Transporter OATP1B3 (OATP8) and the Export Pump ABCC2

    K. Letschert

    págs. 549-620

    

  • Rosuvastatin Attenuates Monocyte-Endothelial Cell Interactions and Vascular Free Radical Production in Hypercholesterolemic Mice

    H. Matsushita, T. Asagami, Wei Li

    págs. 557-569

    

  • Molecular Determinants of Glycine-Independent Desensitization of NR1/NR2A Receptors

    B. Hu, F. Zheng

    págs. 563-593

    

  • Ectonucleoside Triphosphate Diphosphohydrolase1/CD39, Localized in Neurons of Human and Porcine Heart, Modulates ATP-Induced Norepinephrine Exocytosis

    P. M. Heerdt, T. Machida

    págs. 570-585

    

  • Formation, Distribution, and Elimination of Infliximab and Anti-Infliximab Immune Complexes in Cynomolgus Monkeys

    M. R. Cunningham, J. R. Rojas, R. P. Taylor

    págs. 578-667

    

  • Peroxisome Proliferator-Activated Receptor Agonists Modulate Heart Function in Transgenic Mice with Lipotoxic Cardiomyopathy

    R. K. Vikramadithyan

    págs. 586-730

    

  • Clozapine Potentiation of N-Methyl-D-aspartate Receptor Currents in the Nucleus Accumbens: Role of NR2B and Protein Kinase A/Src Kinases

    M. Wittmann, M. J. Marino

    págs. 594-696

    

  • Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis

    S. Fiorucci, C. Clerici, E. Antonelli

    págs. 604-797

    

  • Effects of 4'-Chloro-3alpha-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine

    A. Ebbs, A. H. Newman, G. Tanda

    págs. 613-657

    

  • Transport of the Natural Sweetener Stevioside and Its Aglycone Steviol by Human Organic Anion Transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)

    V. Chatsudthipong, C. Srimaroeng

    págs. 621-646

    

  • The Role of Mitochondrial Uncoupling in 3,4-Methylenedioxymethamphetamine-Mediated Skeletal Muscle Hyperthermia and Rhabdomyolysis

    D. E. Rusyniak

    págs. 629-639

    

  • Specific Antibody Modulates Absorptive Transport and Metabolic Activation of Benzo[a]pyrene across Caco-2 Monolayers

    S. S. De Buck, P. Augustijns

    págs. 640-750

    

  • Mechanistic Pharmacokinetic and Pharmacodynamic Modeling of CHF3381 (2-[(2,3-Dihydro-1H-inden-2-yl)amino]acetamide Monohydrochloride), a Novel N-Methyl-D-aspartate Antagonist and Monoamine Oxidase-A Inhibitor in Healthy Subjects

    C. Csajka, B. P. Imbimbo

    págs. 647-908

    

  • Contribution of alpha~1GABA~A and alpha~5GABA~A Receptor Subtypes to the Discriminative Stimulus Effects of Ethanol in Squirrel Monkeys

    D. M. Platt

    págs. 658-847

    

  • Cloning and Characterization of Cyclooxygenase-1b (Putative Cyclooxygenase-3) in Rat

    J. A. Snipes

    págs. 668-704

    

  • Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8)

    C. P. Bond, M. L. Halls

    págs. 677-687

    

  • Asparagine, Valine, and Threonine in the Third Extracellular Loop of Muscarinic Receptor Have Essential Roles in the Positive Cooperativity of Strychnine-Like Allosteric Modulators

    A. Krejci, J. Jakubik, V. Dolezal

    págs. 688-719

    

  • M~2, M~3, and M~4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons

    H.-M. Zhang

    págs. 697-711

    

  • Inhibition of S-Adenosyl-L-homocysteine Hydrolase Induces Immunosuppression

    Y.-H. Feng, Y.-F. Fu, Q.-L. Wu, J.-X. Wang, W.-L. Zhou

    pág. 705

    

  • Improved Brain Uptake and Pharmacological Activity Profile of Morphine-6-Glucuronide Using a Peptide Vector-Mediated Strategy

    C. Bonnafous, C. Rousselle, J. Temsamani

    págs. 712-739

    

  • The Antiepileptic Drug Levetiracetam Decreases the Inositol 1,4,5-Trisphosphate-Dependent [Ca^2^+]~i Increase Induced by ATP and Bradykinin in PC12 Cells

    V. Lariccia, M. Cataldi

    págs. 720-764

    

  • Down-Regulation of Na^+ Pump alpha~2 Isoform in Isoprenaline-Induced Cardiac Hypertrophy in Rat: Evidence for Increased Receptor Binding Affinity but Reduced Inotropic Potency of Digoxin

    M. Baek, M. Weiss

    págs. 731-789

    

  • Nicotinic Receptor Subtypes in Rat Hippocampal Slices Are Differentially Sensitive to Desensitization and Early in Vivo Functional Up-Regulation by Nicotine and to Block by Bupropion

    E. X. Albuquerque, M. Alkondon

    págs. 740-805