Journal of Pharmacology and Experimental Therapeutics

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  Año 2005, Vol. 314, Número 2

  • The Origins of Diversity and Specificity in G Protein-Coupled Receptor Signaling

    S. Maudsley

    págs. 485-494

    

  • Xrcc3 Induces Cisplatin Resistance by Stimulation of Rad51-Related Recombinational Repair, S-Phase Checkpoint Activation, and Reduced Apoptosis

    M. Loignon, Z.-Y. Xu

    págs. 495-505

    

  • Consequences of Abrupt Glutathione Depletion in Murine Clara Cells: Ultrastructural and Biochemical Investigations into the Role of Glutathione Loss in Naphthalene Cytotoxicity

    K. J. Williams, A. J. Phimister, L. S. Van Winkle

    págs. 506-513

    

  • Tranilast Prevents the Progression of Experimental Diabetic Nephropathy through Suppression of Enhanced Extracellular Matrix Gene Expression

    H. Akahori

    págs. 514-521

    

  • Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

    Y. Wang, Xin Wei, X. Xiao

    págs. 522-532

    

  • Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: A Meta-Analysis of Rat Oatp1a1 and Human OATP1B1

    P. W. Swaan, K. S. Pang, C. Chang

    págs. 533-541

    

  • Protein Kinase C betaII Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury

    R. J. Brue, P. Taormina, D. Omiyi

    págs. 542-551

    

  • beta1 Adrenergic Receptor-Mediated Enhancement of Hippocampal CA3 Network Activity

    C. W. D. Jurgens

    págs. 552-560

    

  • Functional Characterization of the beta-Adrenergic Receptor Subtypes Expressed by CA1 Pyramidal Cells in the Rat Hippocampus

    K. L. Hillman

    págs. 561-567

    

  • Preclinical Profile of Ciclesonide, a Novel Corticosteroid for the Treatment of Asthma

    M. G. Belvisi, D. S. Bundschuh

    págs. 568-574

    

  • Recognition of Benztropine by the Dopamine Transporter (DAT) Differs from That of the Classical Dopamine Uptake Inhibitors Cocaine, Methylphenidate, and Mazindol as a Function of a DAT Transmembrane 1 Aspartic Acid Residue

    C. D. Bondi, A. H. Newman, O. T. Ukairo, A. P. Kozikowski, S. S. Kulkarni

    págs. 575-583

    

  • A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis

    S. Fiorucci

    págs. 584-595

    

  • mu Opioid Receptor Coupling to G~i~/~o Proteins Increases during Postnatal Development in Rat Brain

    H. K. Happe, L. C. Murrin, J. N. Talbot

    págs. 596-602

    

  • The p53 Inhibitor Pifithrin-alpha Is a Potent Agonist of the Aryl Hydrocarbon Receptor

    M. S. Hoagland, E. M. Hoagland

    págs. 603-610

    

  • Systemic Morphine Inhibits Dorsal Horn Projection Neurons through Spinal Cholinergic System Independent of Descending Pathways

    Y.-P. Chen, S.-R. Chen

    págs. 611-617

    

  • Zinc Activates TREK-2 Potassium Channel Activity

    J.-S. Kim, J. Y. Park, H.-W. Kang

    págs. 618-625

    

  • Variability of CYP3A7 Expression in Human Fetal Liver

    J. S. Leeder

    págs. 626-635

    

  • Brain Uptake Kinetics of Nicotine and Cotinine after Chronic Nicotine Exposure

    P. R. Lockman

    págs. 636-642

    

  • Functional Selectivity of Nociceptin/Orphanin FQ Peptide Receptor Partial Agonists on Cardiovascular and Renal Function

    D. R. Kapusta, M. A. Burmeister

    págs. 643-651

    

  • Pharmacodynamic Characterization of ZP120 (Ac-RYYRWKKKKKKK-NH~2), a Novel, Functionally Selective Nociceptin/Orphanin FQ Peptide Receptor Partial Agonist with Sodium-Potassium-Sparing Aquaretic Activity

    D. R. Kapusta, C. Thorkildsen

    págs. 652-660

    

  • Neurochemical and Behavioral Responses to Cocaine in Adult Male Rats with Neonatal Isolation Experience

    X.Y. Zhang, T. A. Kosten

    págs. 661-667

    

  • Methotrexate Preconditioning Allows Sufficient Engraftment to Confer Drug Resistance in Mice Transplanted with Marrow Expressing Drug-Resistant Dihydrofolate Reductase Activity

    L. R. Belur, R. I. James

    págs. 668-674

    

  • Characterization of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred Mice

    E. E. Shannon

    págs. 675-685

    

  • Disodium Disuccinate Astaxanthin (Cardax) Attenuates Complement Activation and Reduces Myocardial Injury following Ischemia/Reperfusion

    S. F. Lockwood, D. A. Lauver, B. R. Lucchesi

    págs. 686-692

    

  • Human CD34-Positive Hematopoietic Stem Cells Constitute Targets for Carcinogenic Polycyclic Aromatic Hydrocarbons

    J. van Grevenynghe

    págs. 693-702

    

  • Hepatic Cytochrome P450 Gene Regulation during Endotoxin-Induced Inflammation in Nuclear Receptor Knockout Mice

    T. A. Richardson

    págs. 703-709

    

  • Evaluation of PAI-039 [{1-Benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic Acid], a Novel Plasminogen Activator Inhibitor-1 Inhibitor, in a Canine Model of Coronary Artery Thrombosis

    J. K. Hennan

    págs. 710-716

    

  • Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABA~A Receptor

    U. Egerland, K. Bernoster, B. Langen

    págs. 717-724

    

  • Quantitative in Vivo Microdialysis Study on the Influence of Multidrug Transporters on the Blood-Brain Barrier Passage of Oxcarbazepine: Concomitant Use of Hippocampal Monoamines as Pharmacodynamic Markers for the Anticonvulsant Activity

    I. Smolders, R. Clinckers

    págs. 725-731

    

  • Barakol Extracted from Cassia siamea Stimulates Chloride Secretion in Rat Colon

    S. Poonyachoti, C. Deachapunya

    págs. 732-737