Genome editing
Anna Petherick
págs. 1-1
Three technologies that changed genetics: Genome editing uses enzymes that are targeted to sequences of dna to make cuts. These cuts are then repaired by the cell'S machinery. This technology allows scientists to disrupt or modify genes with unprecedented precision. By amy maxmen, infographic by denis mallet.
Amy Maxmen
págs. 2-3
Research: Biology'S big hit: Scientists now have several tools to edit the genomes of living organisms. One of the most recent is revolutionizing research and has thrust two of its creators into the limelight.
Zoë Corbyn
págs. 4-5
Perspective: Embryo editing needs scrutiny: Genome-editing presents many opportunities. But the advent of human-germline editing brings urgency to ethical discussions, says jennifer doudna.
Jennifer Doudna
págs. 6-6
Perspective: Encourage the innovators: Rather than emphasize risks that are not entirely new, talks about germline editing should focus more on the benefits, argues george church.
George Church
págs. 7-7
Disease: Closing the door on hiv: Although yet to complete clinical trials, genome editing has already shown promise against a globally important disease.
Michael Eisenstein
págs. 8-9
Medicine: Expanding possibilities: The first therapeutics based on genome-editing tools will treat diseases caused by single genes, but many other factors dictate what is currently possible.
Virginia Gewin
págs. 10-11
Epigenetics: The genome unwrapped: Epigeneticists are harnessing genome-editing technologies to tackle a central question hanging over the community — does their field matter?
Heidi Ledford
págs. 12-13
Q&a: Cocktail maker: Tim lu'S synthetic-biology research at massachusetts institute of technology in cambridge combines biological engineering with electronics and computer science to create bacteria that make structural proteins containing tiny semi-conductors called quantum dots. He explains how genome-editing techniques are furthering his research and their role in treating disease.
Will Tauxe
págs. 14-14
Agriculture: A new breed of edits: Genome editing allows much smaller changes to be made to dna compared with conventional genetic engineering. In terms of agriculture, this might win over public and regulator opinion.
Claire Ainsworth
págs. 15-16
GENOME EDITING: 4 BIG QUESTIONS: Despite the popularity of genome-editing techniques, researchers are still grappling with the known unknowns of the technologies. Here are four of their most pressing questions.
págs. 17-17
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