Journal of Pharmacology and Experimental Therapeutics

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  Año 2004, Vol. 309, Número 3

  • Structures and Models of Transporter Proteins

    S. G. Dahl

    págs. 853-860

    

  • Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-alpha Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo

    R. J. Schmidt, T. P. Beyer

    págs. 861-868

    

  • A Newly Identified Role for Superoxide in Inflammatory Pain

    Z.-Q. Wang, S. Cuzzocrea, F. Porreca

    págs. 869-878

    

  • A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-d ioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters

    K. Tsunemi

    págs. 879-883

    

  • Anthraquinone Polyamines: Novel Channel Blockers to Study N-Methyl-D-Aspartate Receptors

    K. Kashiwagi

    págs. 884-893

    

  • Pharmacokinetics, Safety, and Efficacy of a Liposome Encapsulated Thymidylate Synthase Inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9 -yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric Acid], in Mice

    D. B. Colagiovanni, D. L. Emerson, J. Desjardins

    págs. 894-902

    

  • S32504, a Novel Naphtoxazine Agonist at Dopamine D~3/D~2 Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole

    M. J. Millan

    págs. 903-920

    

  • S32504, a Novel Naphtoxazine Agonist at Dopamine D~3/D~2 Receptors: II. Actions in Rodent, Primate, and Cellular Models of Antiparkinsonian Activity in Comparison to Ropinirole

    M. J. Millan

    págs. 921-935

    

  • S32504, a Novel Naphtoxazine Agonist at Dopamine D~3/D~2 Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole

    M. J. Millan

    págs. 936-950

    

  • Noncompetitive Metabotropic Glutamate~5 Receptor Antagonist (E)-2-Methyl-6-styryl-pyridine (SIB1893) Depresses Glutamate Release through Inhibition of Voltage-Dependent Ca^2^+ Entry in Rat Cerebrocortical Nerve Terminals (Synaptosomes)

    T. S. Sihra, S.-J. Wang

    págs. 951-958

    

  • Effects of Dopamine Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys: Relationship to Transporter Occupancy Determined by Positron Emission Tomography Neuroimaging

    K. P. Lindsey, K. M. Wilcox

    págs. 959-969

    

  • A Novel Selective Peroxisome Proliferator-Activated Receptor alpha Agonist, 2-Methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), Potently Decreases Plasma Triglyceride and Glucose Levels and Modifies Lipoprotein Profiles in KK-A^y Mice

    K. Kuwabara, K. Murakami

    págs. 970-977

    

  • Dual Regulation of Tumor Necrosis Factor-alpha-Induced CCL2/Monocyte Chemoattractant Protein-1 Expression in Vascular Smooth Muscle Cells by Nuclear Factor-kappaB and Activator Protein-1: Modulation by Type III Phosphodiesterase Inhibition

    W.-C. Chiang, Y.-M. Chen

    págs. 978-986

    

  • Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na^+ Channels

    M. Shiraishi, R. A. Harris

    págs. 987-994

    

  • In Vivo Study on Cross Talk between Inducible Nitric-Oxide Synthase and Cyclooxygenase in Rat Gastric Mucosa: Effect of Cycloxygenase Activity on Nitric Oxide Production

    J. Fujii, Y. Iuchi, K. Uno, K. Iijima, H. Sugata

    págs. 995-1002

    

  • In Vitro Characterization of 5-Carboxyl-2,4-di-benzamidobenzoic Acid (NS3763), a Noncompetitive Antagonist of GLU~K~5 Receptors

    J. K. Christensen

    págs. 1003-1010

    

  • Rho/Rho Kinase and Phosphoinositide 3-Kinase Are Parallel Pathways in the Development of Spontaneous Arterial Tone in Deoxycorticosterone Acetate-Salt Hypertension

    E. A. Wehrwein, C. A. Northcott

    págs. 1011-1019

    

  • Benzylamine Exhibits Insulin-Like Effects on Glucose Disposal, Glucose Transport, and Fat Cell Lipolysis in Rabbits and Diabetic Mice

    María del Carmen Iglesias Osma, María Josefa García Barrado

    págs. 1020-1028

    

  • Cyclosporin A, but Not Tacrolimus, Inhibits the Biliary Excretion of Mycophenolic Acid Glucuronide Possibly Mediated by Multidrug Resistance-Associated Protein 2 in Rats

    M. Kobayashi

    págs. 1029-1035

    

  • Ca^2^+-Activated K^+ Channels Underlying the Impaired Acetylcholine-Induced Vasodilation in 2K-1C Hypertensive Rats

    G. E. Callera

    págs. 1036-1042

    

  • Agonist-Induced Serotonin 2A Receptor Desensitization in the Rat Frontal Cortex and Hypothalamus

    K. J. Damjanoska, B. A. Heidenreich

    págs. 1043-1050

    

  • Prodrug Modification Increases Potassium Tricyclo[5.2.1.0^2^,^6]-decan-8-yl Dithiocarbonate (D609) Chemical Stability and Cytotoxicity against U937 Leukemia Cells

    G. P. Meier, A. Bai

    págs. 1051-1059

    

  • Naproxen Reduces Excitotoxic Neurodegeneration in Vivo with an Extended Therapeutic Window

    J. M. Silakova

    págs. 1060-1066

    

  • Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson's Disease

    S. Yamazaki, A. Iwashita

    págs. 1067-1078

    

  • Nitric Oxide Inhibits ATP Release from Erythrocytes

    A. H. Stephenson, J. J. Olearczyk, M. L. Ellsworth

    págs. 1079-1084

    

  • Pharmacokinetics of Recombinant Human Leukemia Inhibitory Factor in Sheep

    A. M. Segrave

    págs. 1085-1092

    

  • 2-Hydroxyestradiol Is a Prodrug of 2-Methoxyestradiol

    L. C. Zacharia

    págs. 1093-1097

    

  • Potent and Metabolically Stable Agonists for Protease-Activated Receptor-2: Evaluation of Activity in Multiple Assay Systems in Vitro and in Vivo

    A. Kawabata

    págs. 1098-1107

    

  • Structural Determinants of the Pharmacological Properties of the GABA~A Receptor alpha6 Subunit

    B. C. Drafts, J. L. Fisher

    págs. 1108-1115

    

  • Effects of Galantamine, a Nicotinic Allosteric Potentiating Ligand, on Nicotine-Induced Catecholamine Release in Hippocampus and Nucleus Accumbens of Rats

    M. Yatsula, B. M. Sharp

    págs. 1116-1123