Journal of Pharmacology and Experimental Therapeutics

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  Año 2004, Vol. 310, Número 3

  • CYP2C44, a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products

    T. C. DeLozier

    págs. 845-854

    

  • Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung

    A. C. Simmonds, B. I. Ghanayem

    págs. 855-864

    

  • Ligand Dependency of 5-Hydroxytryptamine 2C Receptor Internalization

    B. D. Schlag

    págs. 865-870

    

  • Epileptogenesis Causes Acute and Chronic Increases in GABA~A Receptor Endocytosis That Contributes to the Induction and Maintenance of Seizures in the Hippocampal Culture Model of Acquired Epilepsy

    R. E. Blair, D. C. Lawrence, S. Sombati

    págs. 871-880

    

  • Botulinum Toxin Type A Targets RhoB to Inhibit Lysophosphatidic Acid-Stimulated Actin Reorganization and Acetylcholine Release in Nerve Growth Factor-Treated PC12 Cells

    K. Erickson, H. Ishida, Xieping Zhang

    págs. 881-889

    

  • Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

    C. Banfi, L. Sironi, G. De Simoni

    págs. 890-895

    

  • In Vitro Internalization, Intracellular Transport, and Clearance of an Anti-CD11a Antibody (Raptiva) by Human T-Cells

    E. Stefanich, G. P. Coffey

    págs. 896-904

    

  • SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization

    M. Rinaldi-Carmona

    págs. 905-914

    

  • Analysis of the Effects of Cannabinoids on Synaptic Transmission between Basket and Purkinje Cells in the Cerebellar Cortex of the Rat

    M. Than, I. Wallmichrath, B. Szabo, D. Thorn

    págs. 915-925

    

  • Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells

    Huige Li, I. Brausch, N. Xia

    págs. 926-932

    

  • Mechanism of Action of Galantamine on N-Methyl-D-Aspartate Receptors in Rat Cortical Neurons

    S. Moriguchi, W. Marszalec

    págs. 933-942

    

  • Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist

    K. E. Vanover, S. C. Harvey

    págs. 943-951

    

  • Behavioral Characterization of the Novel GABA~B Receptor-Positive Modulator GS39783 (N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

    P. H. Kelly, F. Chaperon, J. F. Cryan

    págs. 952-963

    

  • Effect of BM-573 [N-Terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist, in a Porcine Model of Acute Pulmonary Embolism

    A. Ghuysen, B. Lambermont

    págs. 964-972

    

  • P2X Receptor Activation Elicits Transporter-Mediated Noradrenaline Release from Rat Hippocampal Slices

    L. Papp, F. Erdelyi, T. Balazsa, A. Kofalvi

    págs. 973-980

    

  • Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles

    Ronald J. Tallarida, Y. Grabovsky

    págs. 981-986

    

  • ITH4012 (Ethyl 5-Amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a Novel Acetylcholinesterase Inhibitor with "Calcium Promotor" and Neuroprotective Properties

    C. de los Rios, C. Orozco

    págs. 987-994

    

  • Identification of alpha-1L Adrenoceptor in Rabbit Ear Artery

    Y. Hiraizumi-Hiraoka

    págs. 995-1002

    

  • Strong Protein Adduct Trapping Accompanies Abolition of Acrolein-Mediated Hepatotoxicity by Hydralazine in Mice

    L. M. Kaminskas

    págs. 1003-1010

    

  • Metabolism of N,N',N"-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms

    N. N. Bumpus, M. Webster, E. Harleton

    págs. 1011-1019

    

  • Chronic Antidepressant Treatment Causes a Selective Reduction of mu-Opioid Receptor Binding and Functional Coupling to G Proteins in the Amygdala of Fawn-Hooded Rats

    A. J. Lawrence, F. Chen

    págs. 1020-1026

    

  • Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)~2 Agonist, and Ovine CRF, a CRF~1 Agonist, Differentially Alter Feeding and Motor Activity

    E. P. Zorrilla, L. E. Reinhardt

    págs. 1027-1034

    

  • Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular Monoamine Transporters

    P. A. Crooks, D. K. Miller

    págs. 1035-1045

    

  • An Engineered Cocaine Hydrolase Blunts and Reverses Cardiovascular Responses to Cocaine in Rats

    Stephen Brimijoin, Y. Gao

    págs. 1046-1052

    

  • The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N, N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation

    M. J. Fabis, T. Mikheeva, G. S. Scott, R. B. Kean, J. G. Mabley

    págs. 1053-1061

    

  • Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6

    B. A. Ward, D. A. Flockhart, N. V. Soukhova, Z. Desta

    págs. 1062-1075

    

  • Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood

    K.-i. Matsumoto

    págs. 1076-1083

    

  • Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH~2-Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-~X~L

    L. M. Greene, M. M. Mc Gee

    págs. 1084-1095

    

  • Enhanced Anti-Inflammatory Potency of a Nitric Oxide-Releasing Derivative of Flunisolide: Role of Nuclear Factor-kappaB

    J. L. Wallace

    págs. 1096-1102

    

  • Disposition of Flavonoids via Enteric Recycling: Enzyme-Transporter Coupling Affects Metabolism of Biochanin A and Formononetin and Excretion of Their Phase II Conjugates

    X. Jia, Jun Chen

    págs. 1103-1113