The battle within: cell death by phagocytosis in cancer

• Lujia Zhou ^[1] ; Shiying Fan ^[1] ; Wenjie Zhang ^[2] ; Zhiyuan Gong ^[1] ; Daorong Wang ^[3] ; Dong Tang ^[3]
  1. [1] Yangzhou University

     Yangzhou University

     China

     
  2. [2] Chongqing University

     Chongqing University

     China

     
  3. [3] Department of General Surgery, Institute of General Surgery, Northern Jiangsu People’s Hospital Afliated to Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou 225000, China

  Mostrar afiliaciones +
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 3, 2025, págs. 871-886
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The process by which living cells are phagocytosed and digested to death is called cell death by phagocytosis, a term that has just recently been generalized and redefned. It is characterized by the phagocytosis of living cells and the cessation of cell death by phagocytosis. Phagocytosis of dead cells is a widely discussed issue in cancer, cell death by phagocytosis can stimulate phagocytosis and stimulate adaptive immunity in tumors, and at the same time, do not-eat-me signaling is an important site for cancer cells to evade recognition by phagocytes. Therefore, we discuss in this review cell death by phagocytosis occurring in cancer tissues and emphasize the diference between this new concept and the phagocytosis of dead tumor cells. Immediately thereafter, we describe the mechanisms by which cell death by phagocytosis occurs and how tumors escape phagocytosis. Finally, we summarize the potential clinical uses of cell death by phagocytosis in tumor therapy and strive to provide ideas for tumor therapy.