SLAM family‑mediated crosstalk between tumor and immune cells in the tumor microenvironment: a promising biomarker and a potential therapeutic target for immune checkpoint therapies
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[1] Northeast Ohio Medical University
Northeast Ohio Medical University
Estados Unidos
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 3, 2025, págs. 901-908
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Immune cells infltrating the tumor microenvironment are physiologically important in controlling cancers. However, emerging studies have shown that cancer cells can evade immune surveillance and establish a balance in which these immune cells support tumor progression and therapeutic resistance. The signaling lymphocytic activation molecule family members have been recognized as mediators of tumor microenvironment interactions, and a promising therapeutic target for cancer immunotherapy. This review is focused on the role of SLAM family in tumor and immune cell interactions and discusses how such crosstalk afects tumor behavior. This will shed insight into the next step toward improving cancer immunotherapy.
