The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis

• Autores: Claudia Hass, Jens Lohrmann, Verónica Albrecht, Sang-Dong Yoo, Tong Zhu, Eberhard Schafer, Jörg Kudla
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Nº. 16, 2004, págs. 3290-3302
• Idioma: inglés
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• Resumen

  • Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinin is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.