Immunocytochemical distribution of the AMPA receptor subunits GluR2/3 and GluR4 in the cristae ampullares of the hatched chicken.

• Autores: Izaskun Elezgarai Gabantxo, Diana Hermida Muñiz, A. Flores, N. Puente, Jon Jatsu Azkue Barrenetxea, Pedro Rolando Grandes Moreno
• Localización: European Journal of anatomy, ISSN-e 1136-4890, Vol. 7, Nº. 2, 2003, págs. 79-84
• Idioma: inglés
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• Resumen

  • A preembedding immunoperoxidase method was used to study the distribution of the GluR2/3 and GluR4 AMPA subunits of the ionotropic glutamate receptors in the peripheral vestibular epithelium of the hatched chicken. At the light microscopic level, a strong immunoreactivity for both subunits was observed around type I hair cells in the cristae ampullares. At ultrastructural level, immunoreaction product was accumulated in calyx-type profiles of vestibular ganglion afferent fibres closely attached to type I hair cells. Occasionally, bouton-type endings supposedly on type II hair cells were immunostained for GluR4. These observations, together with the electrophysiological evidence, suggest that GluR2/3 and GluR4 subunits play a role in the transmission of vestibular sensory information during early development of the chicken.