Acromegalia, hiperparatiroidismo primario y feocromocitoma

Mercedes Robledo Batanero ^[2] ; César Alonso Rodríguez ^[1] ; Francisco de Asís Fernández Riestra ^[1] ; Arturo Lisbona Gil ^[1]
1. [1] Hospital Central de la Defensa
  
  Hospital Central de la Defensa
  
  Madrid, España
2. [2] Centro Nacional de Investigaciones Oncológicas
  
  Centro Nacional de Investigaciones Oncológicas
  
  Madrid, España
Localización: Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición, ISSN 1575-0922, Vol. 53, Nº. 6, 2006, págs. 382-386
Idioma: español
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Resumen
- We present the case of a 56-year-old woman who, 5 years after receiving a diagnosis of unilateral adrenal pheochromocytoma and primary hyperparathyroidism, was diagnosed with acromegaly caused by a growth hormone-secreting pituitary adenoma. No germ-line mutations in RET, VHL and MEN-1 gene were detected. Medullar thyroid carcinoma was also ruled out. Therefore, the present case shows coexistence of a tumor characteristic of MEN 2 syndrome (pheochromocytoma) with a growth hormone-secreting pituitary tumor characteristic of MEN 1 syndrome and primary hyperparathyroidism, which can be observed in both multiple endocrine neoplasia syndromes, but without germ-line mutations in RET, VHL and MEN-1.