Resumen de Abordaje epidemiológico de un brote de trastorno conversivo epidémico en adolescentes

S. Navarrete Navarro, Carlos Riebeling Navarro, Juan Manuel Mejía-Arangure, Arnulfo Nava Zavala

• español

  Introducción En la bibliografía mundial existen informes sobre la existencia de brotes del trastorno conversivo epidémico, la mayoría de los cuales se relaciona con personal que labora en fábricas, generalmente bajo condiciones de estrés o presión.

  Los objetivos de este estudio fueron: encontrar el origen o causa del brote en la población afectada, identificar el mecanismo de transmisión del evento, y determinar los factores de riesgo asociados al mismo.

  Material y métodos La investigación incluyó: 1) un censo y la búsqueda activa de los alumnos afectados, 2) la realización de un estudio de casos y controles para identificar factores de riesgo asociados al problema mencionado, 3) toma de muestras de alimentos y bebidas, para su estudio microbiológico y toxicológico, 4) investigación en SEDESOL sobre el grado de contaminación atmosférica.

  Resultados Se identificaron 455 alumnos en el turno matutino. Se detectó un total de 52 casos acordes con la definición operacional, lo cual correspondió a una tasa de ataque de 11.4%; 27 mujeres y 25 hombres. Se entrevistó a todos ellos y se detectó que la frecuencia de síntomas entre los alumnos fue como sigue: desmayo 100%, cefalea 88%, parestesias 56%, dificultad para la movilización de alguna extremidad 35%, ardor de ojos 27%, ardor de nariz 10%, dolor abdominal 3% y vómito 3%. La tasa de ataque fue significativamente más alta en las niñas menores de 15 años (91%) que en las de mayor edad (9%). El género femenino presentó 7 veces mayor riesgo de ser caso y, en relación a la edad, las menores de 15 años tuvieron 4 veces mayor probabilidad de ser casos (p< 0.05). La tasa de ataque por ubicación de los alumnos dentro del plantel fue: planta baja 22.4%, primer piso 7.1% y segundo piso 4.1%. Un 60% de los casos se encontró en dos grupos escolares (1°B y 2°A), estos se encontraban en la planta baja durante el desarrollo del suceso. El pertenecer a alguno de estos dos grupos representó 7 veces más riesgo de ser caso (p<0.05). La bebida "X" que en un inicio fue señalada como la culpable del brote, durante el análisis estadístico mostró una razón de momios menor a uno (factor de protección y no de riesgo). Ninguno de los alimentos examinados resultó positivo en las pruebas de detección de agentes tóxicos y microbiológicos.

  Discusión Las pruebas estadísticas que se realizaron, mostraron que el número atribuible de casos que se explicaría mediante los diferentes riesgos calculados, es muy bajo en relación con el número total de casos. Para complementar estos resultados se realizó un análisis multivariante en aquellas variables que resultaron significativas o con riesgo de ser caso; de esta forma se comprobó que el tener una edad menor a 15 años y pertenecer al sexo femenino son factores interactivos. De la misma manera las variables: ser caso, pertenecer al sexo femenino y comer tortas preparadas en casa, son interactivas, pero el número atribuible de casos sólo explica 32% de ellos, actuando las variables "comer tortas, galletas, dulces y palomitas de maíz", como factores de confusión dentro del análisis. En cuanto al grado de contaminación ambiental, se observó que el nivel de ozono en la zona centro, estaba en rango bajo el día de los hechos y sólo se podría relacionar con molestias oculares o en las vías respiratorias en personas sensibles. Consideramos que si esto hubiera sido el agente etiológico no se hubiera delimitado el problema específicamente al plantel escolar. Las pruebas psicológicas aplicadas a los casos, determinaron que existieron diferencias entre la capacidad de responder a una situación de emergencia y la susceptibilidad a ser influenciable por el medio. Además, la diseminación visual y auditiva fueron las vías a través de las cuales se difundió el brote dentro del plantel. El diagnóstico final al que se llegó por exclusión, fue el de trastorno conversivo epidémico.

• English

  Introduction Several outbreaks of Epidemic Conversión Disorder are occurring in different groups of people in the world. Rather than being viewed as a number of people suffering from individual conversion disorder, epidemic hysteria is considered as a social phenomenon involving otherwise healthy people. We received a report letter from Dirección General de Epidemiología, about the existence of a large number of possible food poisoning cases among students, attending morning sessions at a technical high school, located in the downtown area of Mexico City. Twelve students were driven to the Mexican Red Cross Hospital due to fainting. The aims of this study were to determine the cause of such outbreak in a group of adolescents; to get an adequate explanation about the origin of the event; to identify the event dissemination ways and associates risk factors.

  Methods Study design:

  A matched case-control study was carried out to identify factors associated with the illness. Two control cases were randomly selected from the list of nonill students for each case. Fifty two cases and 104 controls were included.

  Hypotheses:

  Following the good health status determined by the physician at the hospital, we started the initial interview with the students. We reached the following possible hypotheses regarding the origin of this outbreak: first, the event was due to food poisoning; second, to the inhalation of a toxic gas such as carbon monoxide and thirdly, by exposure to high levels of contaminants. Finnaly, it might be a mass event of conversion disorder.

  Variables:

  Among the variables included in the study were: sex, age, class group, location of the student at the time of the out-break, and foods eaten during recess and immediately before the outbreak. All the students present at the time of the outbreak were interviewed using a standard questionnaire.

  Laboratory Simultaneously, samples of the food-products sold in and around the school that day were collected for bacteriologic and chemical analyses, the existence of a gas leak, carbon monoxide source, or any other airborne pollutant was investigated by the research team.

  Analyses:

  The demographic characteristics were analyzed by descriptive statistic; association between risk factors as possible causes of the event was determined by multivariate analysis at 95% confidence interval.

  Results:

  The outbreak occurred in the building of a downtown public school in Mexico City. The school has three floors, surrounding a central yard. There are 11 classrooms, two laboratories, an art workshop and a school medical clinic. The total duration of outbreak was 15 minutes. There were 455 students enrolled in the morning program, all of them were interviewed. A total of 52 cases was identified, among the 455 students, for an attack rate of 11.4%. There were three groups in which no cases were found. The attack rate in girls was 3.9 times higher than in boys. Sixty five percent of the cases occurred in two of the nine classrooms (1° B and 2° A). All the students of one group had been waiting at the patio for over an hour during an interclass break. Case cero was a girl from this group with a previous history of fainting. The outbreak occurred outside class-room in the central yard. Five female classmates of case cero fainted while they were with her in the yard. Cases then spread rapidly to the first floor with an attack rate of 13.2 percent, the second floor had 7.7 percent, and finally the third floor had 2.1 percent. All cases had fainted as per case definition. Additionally, headache was a prominent symptom occurring in 88 percent, paresthesias in 56 percent, and perceived difficulty in moving arms or legs in 35 percent. Also almost a quarter of the cases complained of irritation of the eyes and nose. Within one hour, all had completely recovered. Five days after the problem, three girls fainted; no outbreak occurred.

  Being a girl or belonging to class groups 1°B or 2°A, were the most significant risk factors, with (p 0.001). Also being less than 15 years of age was a significant risk factor for illness. The analysis of food preference data in the cases and controls showed that drinking a fruit beverage "X" was not related to the illness. Foods such as sandwiches, brought from home and cookies, candies and popcorn bought from street venders, had a borderline significant association with the illness. However, the number of cases attributable to these foods was very low. Also, it was difficult to figure out how sandwiches were prepared by mothers of individual students and how this factor could be implicated. No pathogen toxin or toxic chemical were identified in the food samples. Some foods studied in the crude analysis were ruled out in the multivariate analysis. A thorough environmental was negative, there being no evidence of a continuing gas leak or other causes. The pollution levels during that week were reported as being within the normal range, by the Metropolitan Index of Air Quality (IMECA). In order to evaluate psychological factors, individual interviews were carried out. The psychologist found that the cases tended to have one or both parents absent from home due to divorce or death, and their family have been damaged by eco-nomic problems. In addition, psychological testing showed that these cases had higher anxiety levels than controls.

  Discussion According to our findings, this outbreak appears as a Epidemic Conversion Disorder. First, no biologic cause was found for the cases. In addition, there was not any evidence to implicate food poisoning, no source of toxic gas could be identified at the school, and the levels of air pollution were not above normal levels. The clinical presentation was not different from the fainting and paresthesia reported in others studies, nor was sex distribution. One possible explanation for the initial case was the time of sun exposure in the schoolyard. Subsequent spread of the outbreak was due to psychological and extra-medical factors, including publicity by the mass media. Interestingly the spread was stopped immediately after closure of the school for one day. All the findings of the psychological reports, applied by another researcher group add further weight to this conclusion.

  In support to our results, many studies has been reported in which the clinical manifestations are the same that we found. In these reports, the outbreak occurred frequently among women, teenagers, students of elementary and secondary schools and chorus, in whom no organic etiology or precipitant causes can be identified. Some authors have reported that the phenomena is more evident in groups with hormonal changes, rigid discipline used in music bands, and during periods of exams or situations under stress. Such circumstances are more related to the outbreak. Some studies have demonstrated that dysfunctional families, divorced or dead parents, play a mayor role in comparison with other factors such as socioeconomic level, religion or ethnicity. The mechanisms of these events have not been clearly identified. The typical course of a psychogenic epidemic at a workplace progresses from sudden onset, often with dramatic symptoms, to a rapidly attained peak that draws much publicity and is followed by quick disappearance of the symptoms. Over 90% of the affected people are women, and the signs range from dizziness, vomiting, nausea, and fainting to epileptic type seizures, and hyperventilation. Predisposing factors include boredom, physical stressors, poor labor-management relations, impaired interpersonal communications and lack of social support. The rapid spread in the conversion disorder, is by visual contact; the treatment should be directed towards the underlying stressors but the out-break may be prolonged. In Epidemic Conversion Disorder the abnormality is confined to group interactions. This outbreak shows the importance of psychological support in populations with risk factors of presenting the illness. The social problems among large populations produce an unforgettable painful experience, mainly among teenagers who dealt with the psychological damage with-out any support.