The effects of DPC (diphenylamine-2-carboxylate-10-4 M) have been studied on the transepithelial potential difference of anterior and posterior gills and on the Cl- fluxes in posterior gills of the Chinese crab Eriocheir sinensis acclimated to fresh water. DPC is effective only on the serosal side of the posterior gills. It induces a marked depolarization of the epithelium and largely reduces the Cl- uptake which takes place in these gills. The observed effects of DPC are consistent with a role of serosal Cl- channels in the transepithelial transport of Cl- taking place in the posterior gills of Eriocheir sinensis.
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