Resumen de CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARg gene
A. Marti, M. Corbalán, Miguel Ángel Martínez González, Lluís Forga Llenas, José Alfredo Martínez Hernández
Obesity in humans results from combined effects of genes, environment and lifestyles. A case-control study (obese vs. lean controls) was conducted to assess the possible association between obesity risk and the Pro12Ala polymorphism of the PPARg gene depending on the dietary intake.The study population comprised 313 Spanish subjects (66 men), which were gender and age-matched. Dietary intake was assessed through a validated food frequency questionnaire for epidemiological studies. Blood samples were taken for the extraction of genomic DNA from leukocytes in order to identify Pro12Ala gene polymorphism. This polymorphism was found similarly in obese (21.4%) and in controls (19.5%). Although the carbohydrate (CHO) intake was not statistically different among groups (p>0.05), the macronutrient distribution of the intake appeared as an effect modifier, since among those individuals with higher carbohydrate intake (>49% E), an increased obesity risk (ORa=5.12, p<0.04; IC95%:1.01-25.80) accompanied the occurrence of the polymorphism. In summary, despite that the studied gene polymorphism had not a direct effect on obesity risk, the results suggest that there are individual differences in the susceptibility to the dietary intake and confirm that gene-diet interactions may have a role in obesity prevalence and in the dietary management of obesity
