IGF-I does not improve fat malabsorption in cirrhotic rats.

• Autores: R. Pérez, Inmaculada Castilla Cortázar, M. Núñez, A. Prado Cabrero, Eduardo Mirpuri Merino, María Inmaculada García Fernández, Salvador González Barón, A. Picardi
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 57, Nº. 1, 2001, pág. 59
• Idioma: inglés
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• Resumen

  • The aim of this study was to explore whether IGF-I treatment for two weeks modified fat intestinal absorption, measured from faecal content, in cirrothic and healthy rats. Male Wistar rats were used. Liver cirrhosis was induced by carbon tetrachloride (CCl4) inhalation twice a week for 11 weeks and phenobarbital addition to drinking water (400 mg/l) 1 week before an during the period of CCl4 exposure. Both control and cirrhotic rats were randomly assigned to two different groups to receive .the vehicle or IGF-I (2 mg/100mg bw day). The results show that faecal lipid content in cirrhotic animals significantly increases as compaired to control groups and no differences are found between untreated and IGF-treated cirrhotic animals. In summary, fat malabsorption observed in cirrothic animals is not corrected by the treatment with IGF-I