Transcriptional Control of the Pgc-1[alpha] Gene in Skeletal Muscle In Vivo.

• Autores: Zhen Yan, Ping Li, Takayuki Akimoto
• Localización: Exercise and sport sciences reviews: a quarterly publication of the American College of Sports Medicine, ISSN 0091-6331, Vol. 35, Nº. 3, 2007, págs. 97-101
• Idioma: inglés
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• Resumen

  • Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor [gamma] coactivator 1[alpha] gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1[alpha] gene in skeletal muscle in vivo.