Influence of Physical Activity on Mortality in Elderly with Coronary Artery Disease

• Autores: Ilona Jansen, Courtney Jolliffe
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 38, Nº. 3, 2006, págs. 418-423
• Idioma: inglés
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• Resumen

  • Purpose: The primary objectives were to 1) examine the dose-response relationship between physical activity and mortality in individuals with CAD, and 2) determine whether the aforementioned relationship is consistent within strata of other personal characteristics.

    Methods: Subjects included 1045 elderly men and women with CAD from the Cardiovascular Health Study. In the first set of analyses, the dose-response relationship between baseline leisure-time physical activity level and all-cause mortality risk over 9 yr was determined using Cox proportional hazards regression models. Next, the subjects were stratified based on several different characteristics, and the consistency of the relationship between baseline leisure-time physical activity and mortality risk within the various strata was determined.

    Results: Baseline leisure-time physical activity was related to all-cause mortality risk in a curvilinear dose-response manner such that greater differences in mortality risk were seen at the lower end of the energy expenditure scale, with a plateau occurring at approximately 4000 kcal[middle dot]wk-1. Within various strata of sex, age, smoking, adiposity, self-perceived health status, number of comorbid conditions, and type of CAD; the relative risks of mortality were lower in active participants (>=1500 kcal[middle dot]wk-1) in comparison with inactive participants (<1500 kcal[middle dot]wk-1).

    Conclusion: This study highlights the inverse graded relationship between physical activity and all-cause mortality in men and women with CAD. Physical inactivity was a risk factor for mortality regardless of whether the subjects were men or women, old or very old, smokers or nonsmokers, lean or overweight, or otherwise healthy or unhealthy.