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The Two Faces of BRCA2, a FANCtastic Discovery: Preview

  • Grant Stewart [1] ; Stephen J. Elledge [1]
    1. [1] Howard Hughes Medical Institute

      Howard Hughes Medical Institute

      Estados Unidos

  • Localización: Molecular cell, ISSN 1097-2765, Vol. 10, Nº 1, 2002, págs. 2-4
  • Idioma: inglés
  • Texto completo no disponible (Saber más ...)
  • Resumen
    • The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.


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