Nuclear Export of NF90 Is Required for Interleukin-2 mRNA Stabilization

• Autores: J. Shim, H. Lim, J. R. Yates
• Localización: Molecular cell, ISSN 1097-2765, Nº 10, 2002, págs. 1331-1344
• Idioma: inglés
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• Resumen

  • In response to T cell activation signals, the half-life of interleukin-2 (IL-2) mRNA is greatly extended. The cis elements mediating IL-2 mRNA stabilization are located in its 5′ and 3′ untranslated regions (UTR). The 3′UTR also contains AU-rich elements (AREs) that mediate rapid IL-2 mRNA degradation in the cytoplasm of nonstimulated T cells. NF90, a previously described RNA binding protein, binds to a subregion of the 3′UTR that contains several AREs and slows down the degradation of IL-2 mRNA. In nonstimulated cells, NF90 is mostly nuclear, but T cell activation results in its accumulation in the cytoplasm. The nuclear export of NF90 is required for IL-2 mRNA stabilization.