Nuclear Receptor Ligands and Cofactor Recruitment: Is There a Coactivator “On Deck”?

• Autores: Kendall W. Nettles, Geoffrey L. Greene
• Localización: Molecular cell, ISSN 1097-2765, Vol. 12, Nº 4, 2003, pág. 850
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.