Resumen de Tome-1, wee1, and the Onset of Mitosis: Coupled Destruction for Timely Entry

Hong Hwa Lim, Uttam Surana

• In a recent issue of Cell, Ayad et al. 2003 report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCF. Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.