Structure of human ACE gives new insights into inhibitor binding and design

• Autores: Keith Brew
• Localización: Trends in pharmacological sciences, ISSN 0165-6147, Vol. 24, Nº 8, 2003, pág. 391
• Idioma: inglés
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• Resumen

  • Angiotensin-converting enzyme (ACE) is a primary target of drugs used for controlling hypertension. A new X-ray crystallographic structure of the key catalytic domain of ACE provides detailed information about the structure of its active site, located in a deep channel, and its interactions with an inhibitor. Such information might facilitate the rational design of ACE inhibitors that are more potent and more selective and therefore of clinical use.