Centrosome size is controlled by centriolar SAS-4

• Jeffrey L. Salisbury ^[1]
  1. [1] Mayo Clinic

     Mayo Clinic

     City of Rochester, Estados Unidos

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 13, Nº 7, 2003, págs. 340-343
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.