Resumen de Secretory granules: and the last shall be first…

Michele Solimena, Hans-Hermann Gerdes

• By tagging secretory granules with the fluorescent protein dsRed-E5, which changes its emission from green to red over time, Duncan et al. analysed the age-dependent distribution of secretory vesicles within chromaffin cells. This elegant study illustrates as never before how age is a critical factor that segregates granules with respect to their localization and mobility and the probability of them undergoing exocytosis in response to different stimuli.