Nogo and its paRTNers

• Thomas Oertle ^[1] ; Martin E. Schwab ^[1]
  1. [1] University of Zurich

     University of Zurich

     Zürich, Suiza

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 13, Nº 4, 2003, págs. 187-194
• Idioma: inglés
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• Resumen

  • Reticulons (RTNs) are a relatively new eukaryotic gene family with unknown functions but broad expression and peculiar topological features. RTNs are widely distributed in plants, yeast and animals and are characterized by a ∼200-amino-acid C-terminal domain, including two long hydrophobic sequences. Nogo/RTN4 can inhibit neurite growth from the cell surface via specific receptors, whereas more general, ‘ancestral’, RTN functions might relate to those of the endoplasmic reticulum – for example, intracellular trafficking, cell division and apoptosis. Here, we review the taxonomic distribution and tissue expression of RTNs, summarize recent discoveries about RTN localization and membrane topology, and discuss the possible functions of RTNs.