Mechanisms of enveloped RNA virus budding

• Owen Pornillos ^[1] ; Jennifer E. Garrus ^[1] ; Wesley I. Sundquist ^[1]
  1. [1] University of Utah

     University of Utah

     Estados Unidos

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 12, 2002, págs. 569-579
• Idioma: inglés
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• Resumen

  • To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. This new model of virus budding has many potential implications for cell biology and viral pathogenesis.