Rhodium (II) hydroxyl carboxylates (rhodium gluconate, lactobionate and lactate). Synthesis, characterization and in vitro cytostatic assays

• Autores: E. S. Gil, E. I. Ferreira, A. C. Valderrama, S. B. Zyngier, R. Najjar
• Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4 2, 2000, pág. 5
• Idioma: inglés
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• Resumen

  • The synthesis, characterization and biological assays of two new rhodium carboxy- lates carbohydrate derivatives, rhodium gluconate Rh2(Gli)4 and lactobionate Rh2(Lab)4 are herein described. These compounds showed good water solubility and low toxicity for fe- male mice in dosis higher than 200 mg/kg. The cytostatic activity was carried out in vitro against K-562 cells and compared with other hydroxyl carboxylate, the rhodium lactate Rh2(Lac)4, which was recently described and synthesized in our laboratory by an alternative route. The derivatives showed low in vitro activity but due to the low toxicity they can be considered as promising carboxylate carriers of antineoplasic drugs that can form adducts in the axial positions.