Augmented Muscle Vasodilatory Responses in Obese Children With Glu27 ß2-Adrenoceptor Polymorphism

• Autores: Alexandre da Gama Moreira Silva, Mauricio M. Ribeiro, Ivani C. Trombetta
• Localización: Pediatric exercise science, ISSN 0899-8493, Vol. 20, Nº. 2, 2008, págs. 157-168
• Idioma: inglés
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• Resumen

  • This study examined forearm vasodilatation during mental challenge and exercise in 72 obese children (OC; age = 10 ± 0.1 years) homozygous with polymorphism in the allele 27 of the ß2-adrenoceptors: Gln27 (n = 61) and Glu27 (n = 11). Forearm blood flow was recorded during 3 min of each using the Stroop color-word test (MS) and handgrip isometric exercise. Baseline hemodynamic and vascular measurements were similar. During the MS, peak forearm vascular conductance was significantly greater in group Glu27 (? = 0.35 ± 0.4 vs. 0.12 ± 0.1 units, respectively, p = .042). Similar results were found during exercise (? = 0.64 ± 0.1 vs. 0.13 ± 0.1 units, respectively, p = .035). Glu27 OC increased muscle vasodilatory responsiveness upon the MS and exercise.