Resumen de Cinética de liberación de cefalexiana desde un biomaterial compuesto por HAP-200/POVIAC/CaCO3
Javier Aragón Fernández, Ramón González Santos, Gastón Fuentes Estévez
The main objective of this work is to study the kinetics of cefalexine release from a biomaterial compound developed recently, to show that it can be used as a controlled release system, for extended periods of time. Besides, different mathematical models were adjusted to the release profiles obtained in each formulation, with the purpose of determine the mechanism by which occurs the release of cefalexine from a composite release system. It was shown that the model proposed by Peppas and Sahlin was that the best fit presented, because, takes into account the phenomenon of Fickian diffusion and the phenomena of relaxation for polymeric chains. In all cases the effect burst was discarded, for what can affirm that almost all the medicine is occluded inside the formulations and not on the surface of these. It could be that the cefalexine is released through a phenomenon of Fickian diffusion through the pores or channels formed in the compound delivery system. Moreover, the phenomenon of relaxation for polymeric chains does not show a strong contribution to the release of cefalexine, but its inclusion in the equation, is necessary to obtain an appropriate mathematical adjustment.
