Evidence-based consensus recommendations to improve the quality of life in prostate cancer treatment
- Autores: Francesc Casas, Josep Maria Borràs Andrés, Ferran Ferrer González, Núria Guañabens Gay, Rafael Gutiérrez del Pozo, Concepción León, José López Torrecilla, Begoña Mellado, Juan Morote Robles, Manuel Puig Domingo, María José Ribal Caparrós, Almudena Zapatero Laborda, Agustí Serra, Valentí Valls
- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 12, Nº. 5, 2010, págs. 346-355
- Idioma: inglés
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Resumen
Introduction Prostate cancer (PC) is one of the tumours with the highest incidence in recent years. PC therapies have several adverse effects. A panel consensus recommendation has been made to prevent or ameliorate complications in PC treatment to improve quality of life.
Material and methods Fifteen specialists have met to analyse the different toxicities associated with PC treatment. Each medical specialist performed a National Library of Medicine PubMed search citations searching about these secondary effects and his speciality from 1999 to 2009 to propose measures for their prevention/amelioration.
Results Surgery is associated with incontinence and impotence. Radiotherapy can produce acute, late urological and gastrointestinal toxicity. Brachytherapy can produce acute urinary retention. Chemotherapy is associated with haematotoxicity, peripheral neuropathy and diarrhoea, and hormone therapy can produce osteoporosis, metabolic syndrome, cognitive and muscular alterations, cardiotoxicity, etc.
Conclusions Improvement in surgical techniques and technology (IMRT/IGRT) can prevent surgical and radiotherapeutic toxicity, respectively. Brachytherapy toxicity can be prevented with precise techniques to preserve the urethra. Chemotherapy toxicity can be prevented with personalised schedules of treatment and close follow-up of iatrogenia and hormone therapy toxicity can be prevented with close follow-up of possible secondary effects.
