El Ying y el Yang de los telómeros: cáncer y envejecimiento

• Autores: María Antonia Blasco Marhuenda
• Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 1, 2010, págs. 105-118
• Idioma: español
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• Resumen

  • Telomeres are a ribonucleoproteic complex at the end of chromosomes which are essential for chromosome protection and genomic stability. Telomeres are DNA tandem repetitions of a rich sequence in G base (TTAGGG at all vertebrales) to that thay join a six proteins complex called �shelterins�, wich includes the heterodimer Pot1-TPP1 and to the proteins of union to the telomere TRF1 and TRF2, and to their interaction factors Rap1 and Tin2.