Targeting cytoskeleton reorganisation as antimetastatic treatment

• Autores: Miguel Quintela-Fandino, Antonio González Martín, Ramón Colomer Bosch
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 12, Nº. 10, 2010, págs. 662-669
• Idioma: inglés
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• Resumen

  • Metastatic relapse is responsible for 90% of cancer-related deaths. The process of distant spreading is a cascade of events that is regulated in a highly complex manner; one cellular phenomenon underlying all the events is cytoskeletal reorganisation. Despite the fact that the ability to leave the primary site and establish a viable mass in a distant site is a hallmark of cancer, targeting cytoskeletal reorganisation is an emerging field. In this review we describe the key signalling pathways controlling cytoskeletal reorganisation and the current targeted therapies against the �druggable� nodes. Finally, we discuss potential implications of trial design that can play a role in detecting the specific activity of this drug class.