Prevention of Mother-to-Child Transmission of HIV: Antiretroviral Strategies

• Autores: J. Read
• Localización: Clinics in Perinatology, ISSN 0095-5108, Vol. 37, Nº. 4, 2010, págs. 765-776
• Idioma: inglés
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• Resumen

  • The World Health Organization's Strategic Approaches to the Prevention of HIV Infection in Infants includes 4 components: primary prevention of HIV-1 infection; prevention of unintended pregnancies among HIV-1�infected women; prevention of transmission of HIV-1 infection from mothers to children; and provision of ongoing support, care, and treatment to HIV-1�infected women and their families. This review focuses on antiretrovirals for secondary prevention of HIV-1 infection�prevention of HIV-1 transmission from an HIV-1�infected woman to her child. Antiretroviral strategies to prevent the mother-to-child transmission of HIV-1 in nonbreastfeeding populations comprise antiretroviral treatment of HIV-1�infected pregnant women needing antiretrovirals for their own health, antiretroviral prophylaxis for HIV-1�infected pregnant women not yet meeting criteria for treatment, and antiretroviral prophylaxis for infants of HIV-1�infected mothers. The review primarily addresses antiretroviral strategies for nonbreastfeeding, HIV-1�infected women and their infants in resource-rich settings, such as the United States. Antiretroviral strategies to prevent antepartum, intrapartum, and early postnatal transmission in resource-poor settings are also addressed, albeit more briefly.