Resumen de Evaluation of ototoxicity in children treated for retinoblastoma:: preliminary results of a systematic audiological evaluation

Patricia Helena Pecora Liberman, Christiane Schultz, María Valéria Schmidt Goffi Gómez, Célia B. G. Antoneli, Martha Motoro Chojniak, Paulo Eduardo Novaes

• Background The objective of this study was to identify the ocurrence of hearing loss in children treated for retinoblastoma using a multidisciplinary approach.

  Patients and methods Thirty-two children were evaluated pre- and post-treatment. Eleven children were treated exclusively with enucleation, fifteen with carboplatin and six with cisplatin. Otoacoustic emissions were performed with the ILO 88, before and after the treatment.

  Results In our study we found 5 children (24%) with hearing loss among the 21 evaluated. However in the group of children treated with carboplatin (N=15), 1 case (6.6%) presented hearing loss, while among those treated with cisplatin (N=6) we found 4 cases (66.6%) with hearing loss (p=0.0114).

  Conclusion We concluded that patients who are treated with cisplatin are at risk for developing hearing loss.