La energía de activación como marcador de heterogeneidad enzimática: Utilidad en bioquímica clínica

• Autores: José Carlos Tutor Valcarce
• Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4, 2010, págs. 493-516
• Idioma: español
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• Resumen

  • The energy of activation (Ea) may provide interesting data in the studies of enzyme heterogeneity characterization, both for enzyme systems having true isoenzymes or molecular forms with a post-transcriptional source. In this article a bibliographical review is carried out on the previously published results for several enzymes with diagnostic usefulness, as the creatine kinase, a-amylase, lactate dehydrogenase, aspartate aminotransferase, alkaline phosphatase, ?-glutamyltransferase, 5´-nucleotidase, alanine aminopeptidase, and ß-N-acetylhexosaminidase. Likewise, possible investigation lines are suggested, in which this thermodynamic variable would to give interesting data for other enzymes with clinical usefulness