PKC-O function at the immunological synapse: prospects for therapeutic targeting

• Autores: Alexandra Zanin Zhorov, Michael L. Dustin, Bruce R. Blazar
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 32, Nº. 8, 2011, págs. 358-363
• Idioma: inglés
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• Resumen

  • Protein kinase C (PKC)-O regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-O in T cells is complex. PKC-O plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-O is required for the development of natural CD4+Foxp3+ regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-O in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-O in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.