Friend or foe: using systems biology to elucidate interactions between fungi and their hosts

• Autores: Lisa Rizzetto, Duccio Cavalieri
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 19, Nº. 10, 2011, págs. 509-515
• Idioma: inglés
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• Resumen

  • Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. In a �systems biology� perspective, the microbiota and host should be seen as an ecosystem, and disease considered as an alteration of the equilibrium. This review addresses host�fungus interaction with a special focus on systems biology approaches to investigate the mechanisms developed by Candida albicans and Aspergillus fumigatus to circumvent host immune responses during fungal infections. Such genome-wide integrative approaches hold the promise to significantly improve our ability to understand which fungal traits can be considered potential threats and the regulatory networks involved in immune subversion.