Microbial-induced immunomodulation by targeting the NF-KB system

• Autores: Andrew S. Neish, Michael Naumann
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 19, Nº. 12, 2011, págs. 596-605
• Idioma: inglés
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• Resumen

  • Virtually all eukaryotes have developed defense mechanisms to efficiently counter potential threats from prokaryotic microorganisms; an example is the conserved nuclear factor-kappaB (NF-?B) signaling system. However, bacterial pathogens and commensals have in turn evolved highly effective counter mechanisms to modulate this immune regulatory circuit. Modifications in ubiquitin, ubiquitin-like (Ubl) proteins such as neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) and other post-translational modifications (PTMs) in the NF-?B system represent attractive targets for microbial manipulation. In this review, we describe recent advances in understanding the different strategies that bacteria have evolved to interfere with PTMs in NF-?B signal transmission.