Health Claims on the Benefits of Moderate Alcohol Consumption in Relation to Genetic Profiles

• Autores: D. P. van Velden, M.J. Kotze, D.M. Blackhurst, J. L. Marnewick, M. Kidd
• Localización: Journal of wine research, ISSN 0957-1264, Vol. 22, Nº 2, 2011, págs. 123-129
• Idioma: inglés
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• Resumen

  • A total of 43 individuals were included in a study of genetic and environmental factors associated with cardiovascular disease; seven subjects (16%) were diagnosed with the metabolic syndrome. A statistically significant association was observed between the E2 allele of the apolipoprotein E (Apo E) polymorphism and an increasing number of metabolic syndrome features (p = 0.03). Clinical and biochemical abnormalities identified could be ascribed to the combined effects of unfavorable genotypes and environmental factors known to interact with the Apo E gene. Excessive alcohol intake, high-calorie diets and smoking should be restricted in individuals with the Apo E2 and/or E4 alleles, which are associated with a significantly increased risk of cardiovascular disease.