Resumen de Tyrosine kinase inhibitors and drug interactions:: a review with practical recommendations
Bella Pajares Hachero, Esperanza Torres Sánchez, José Manuel Trigo Pérez, María Isabel Sáez Medina, Nuria Ribelles Entrena, Begoña Jiménez, Emilio Alba
The adverse effects associated to traditional chemotherapy are well known and broadly studied. In the recent years several tyrosine kinase inhibitors have been approved for cancer treatment and numerous are under investigation. These drugs target specific mutated/overexpressed tyrosin kinase receptors and frecuently their pharmacokinetic/pharmacodinamic behavior is not fully elucidated. These new drugs may interact with non-antineoplastic drugs leading to undesirable adverse effects. In this article, we will discuss different types of drug interactions and briefly review the pharmacokinetics and mechanisms of action of tyrosine kinase inhibitors in clinical use, with a particular emphasis on the risk of the occurrence of such interactions based on currently available scientific evidence.
