Masculinization of XX Drosophila transgenic flies expressing the Ceratitis capitata DoublesexM isoform

• Autores: Giuseppe Saccone, Marco Salvemini, Attilio Pane, Lino C. Polito
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 52, Nº. 8, 2008, págs. 1051-1057
• Idioma: inglés
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• Resumen

  • The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.