Abundance of Circulating Preadipocyte Factor 1 in Early Life

• Autores: F. de Zegher, Marta Díaz, G. Sebastiani, Ana Martín Ancel, David Sanchez Infantes, Abel López-Bermejo, Lourdes Ibáñez
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 35, Nº. 4, 2012, págs. 848-849
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses. We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3. At birth, Pref-1 levels were ~100-fold higher than in adults, being in SGA fetuses ~50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns. Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life.