Anti-inflammatory effects of curcumin in a murine model of chronic asthma

• Autores: M. Karaman, F. Firinci, S Cilaker, P. Uysal, K Tugyan, Osman Yilmaz, N. Uzuner, Ö. Karaman
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 40, Nº. 4, 2012, págs. 210-214
• Idioma: inglés
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• Resumen

  • Background Curcumin, a dietary pigment responsible for the yellow colour of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects.

    Methods Forty-two BALB/c mice were divided into six groups: I, II, III, IV, V, and control group. All groups except the controls were sensitised and challenged with ovalbumin. Group I received nebulised saline in challenge period. Mice in groups II, III, IV, and V were administered curcumin at a dose of 10mg/kg, curcumin 20mg/kg, dexamethasone 1mg/kg, and dimethyl sulfoxide 1mg/kg, respectively, intraperitoneally once a day for the final 5 days of the challenge period. Animals were sacrificed 24h after the last drug administration and the airway samples were evaluated histologically by light microscopy.

    Results All histological parameters in Group III improved similar to Group IV when compared to Group I. In Group II, only thickness of epithelium was significantly lower compared with regard to Group I. All variables except epithelium thicknesses were found to be significantly better in Group III compared to Group II.

    Conclusions In our study, we demonstrated that curcumin administration alleviates the pathological changes of chronic asthma. Curcumin might be a promising therapy for asthma in the future.