Resumen de Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects With Type 2 Diabetes: A randomized double-blind trial
Stefanie Brunner, Ines Holub, Stephan Theis, Andrea Gostner, Ralph Melcher, Petra Wolf, Ulrike Amann Gassner, Wolfgang Scheppach, Hans Hauner
To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control in patients with type 2 diabetes. One hundred ten patients with type 2 diabetes were randomized to receive sweet foods containing either 50 g/day isomaltulose or sucrose for 12 weeks as pan of their habitual diet under free-living conditions. HbA^sub 1c^ at 12 weeks was the primary outcome parameter. In the final analysis comprising 101 patients, isomaltulose did not significantly affect HbA^sub 1c^ at 12 weeks (sucrose: 7.39 ± 0.78%; isomaltulose: 7.24 ± 0.76%; regression coefficient [b]: 0.02 [95% CI: -0.21 to 0.25], P = 0.844). Triglycerides at 12 weeks were significantly lower in the isomaltulose versus the sucrose group (b: 34.01 [6.59-61.44], P = 0.016). Other secondary parameters did not significantly differ between groups. Isomaltulose did not influence glycemic control assessed as HbA^sub 1c^ in type 2 diabetes under free-living conditions but was associated with lower triglyceride levels.
