Serum Albumin in Relation to Change in Muscle Mass, Muscle Strength, and Muscle Power in Older Men

• Autores: Caryn K. Snyder, Jodi A. Lapidus, Peggy M. Cawthon, Thuy-Tien L. Dam, Lynn Y. Sakai, Lynn M. Marshall
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 60, Nº. 9, 2012, págs. 1663-1672
• Idioma: inglés
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• Resumen

  • Objectives: To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power.

    Design: Prospective cohort.

    Setting: Six U.S. academic medical centers.

    Participants: Community-dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study.

    Measurements: Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two-year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants.

    Results: Baseline serum albumin <40 g/L was not associated with 2- or 4.6-year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1�2 g/L) in serum albumin over 2 years exhibited a modest change of -8.9 W (95% CI = -25.6 to -7.8 W) and -6.3 W (95% CI = -21.2 to -8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration.

    Conclusion: Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.