Sarcoidosis simulando una histiocitosis no Langerhans, tratada con antagonistas del factor de necrosis tumoral a

• Autores: G. Hebe Petiti Martin, María Castellanos González, J. Sanz Bueno, M. Burgués Calderón, M. Villar Buill, Francisco Vanaclocha Sebastián, José Luis Rodríguez Peralto
• Localización: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP ), ISSN-e 1696-4608, ISSN 1695-4033, Vol. 77, Nº. 4, 2012, págs. 267-271
• Idioma: español
• Títulos paralelos:
  • Misdiagnosed childhood sarcoidosis as non-Langerhans� cell histiocytosis treated with tumor necrosis factors- antagonists
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• Resumen

  • Abstract Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin.

    Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans� cell histiocytosis (non-LCH).

    We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH.

    She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered.In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor- antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease.