Expression of Sox family genes in early lamprey development
- Autores: Benjamin R. Uy, Marcos Simoes Costa, Tatjana Sauka-Spengler, Marianne E. Bronner
- Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 56, Nº. 5, 2012, págs. 377-383
- Idioma: inglés
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Resumen
Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during the emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4-14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and di-vergence in paralog deployment occurring during early vertebrate evolution.
