CKD-EPI is the most reliable equation to estimate renal function in patients with systemic lupus erythematosus

• Autores: Marco Ulises Martínez Martinez, Peter Mandeville, Lilia María de Guadalupe Llamazares Azuara, Carlos Abud Mendoza
• Localización: Nefrología: publicación oficial de la Sociedad Española de Nefrología, ISSN 0211-6995, Vol. 33, Nº. 1, 2013, págs. 99-106
• Idioma: inglés
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• Resumen

  • No study has determined the best equation for estimating renal function in patients with systemic lupus erythematosus (SLE), starting from a gold standard test. Objective: To evaluate the performance of cistatin/creatinine based equations for estimating renal function in patients with SLE. Methods: We conducted two phases: the first phase included 14 patients in which iothalamate clearance was used to determine the glomerular filtration rate (GFR) and compared with different equations based on cystatin C and/or creatinine.

    In the second phase, we used the best equation (a cystatin and creatinine-based equation) as �reference standard� to compare 5 creatinine-based equations in 55 patients with SLE. Results: In the first phase the equation developed by Stevens and colleagues (based on creatinine and cystatin C), was the best equation. In phase 2, the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation was the best equation with bias of -2.1ml/min/1.73, accuracy (P30) of 94.5% and precision (interquartile range of differences) of -2.1 ml/min/1.73. Conclusions: Our data suggest that CKD-EPI is the best creatinine-based equation to estimate GFR in patients with SLE.